Amyotrophic lateral sclerosis : advances and perspectives of by Kasugai, Yu; Machtoub, Lina

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By Kasugai, Yu; Machtoub, Lina

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3. 4. 5. sensory dysfunction sphincter abnormalities autonomic nervous system dysfunction anterior visual pathway abnormalities movement abnormalities associated with probable Parkinson’s disease defined by DATATOP criteria 6. cognitive abnormalities associated with clinical Alzheimer’s disease as defined by NINCDS-ADRDA criteria If these clinical findings occur, then close attention should be paid to the possible diagnosis of other disease processes. LMN and UMN signs may occur together with other clinical signs in disease where the pathologic process is not primary motor neuron degeneration.

However, the involvement machtoub–ALS October 23, 2015 12:42 PSP Book - 9in x 6in machtoub–ALS ALS Neuroimaging Features of the regions with probable electrophysiological evidence of LMN degeneration or one region with probable and one region with possible electrophysiological evidence of LMN degeneration carries the same weight as one region with definite evidence of LMN degeneration in upgrading the certainty of diagnosis of ALS. A single region with electrophysiological evidence of probable LMN degeneration or two regions with electrophysiological evidence of possible LMN degeneration can be used to upgrade the certainty of the diagnosis of ALS from possible ALS to probable ALS, but not from probable ALS to definite ALS.

Mild abnormalities of polysomnography 5. mild abnormalities of electronystagmography machtoub–ALS 53 October 23, 2015 12:42 PSP Book - 9in x 6in 54 Diagnostic Criteria of Amyotrophic Lateral Sclerosis Electrophysiological features that are inconsistent with the diagnosis of ALS or suggest the presence of additional disease processes include one or more of the following: 1. focal reduction in compound muscle action potential or more than 10% in a 4 cm segment 2. motor conduction velocities, F-wave latencies, or H-wave amplitudes which are more than 30% above established normal values 3.

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