Aminopyridines and Similarly Acting Drugs: Effects on by P. Lechat, S. Thesleff and W. C. Bowman (Eds.)

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By P. Lechat, S. Thesleff and W. C. Bowman (Eds.)

Offers a close assessment of present study into the organic results of aminopyridines and equally performing ingredients. It specializes in their results on ion channels, and at the transformations of contractility that they produce. The points coated variety from biophysical stories of simple mechanisms of motion to the particular and capability medical makes use of in human sufferers

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Additional resources for Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses. Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27–29, 1981

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And Y. P i c h ó n ( 1 9 7 4 ) . S e l e c t i v e i n h i b i t i o n of p o t a s s i u m c u r r e n t in the g i a n t a x o n of the c o c k r o a c h . J. P h y s i o l . ( L o n d . ) , 2 4 2 , 90-91 P. R a n g , H. P. and J. M . R i t t e r (1970) . O n the m e c h a n i s m of d e s e n s i t i zation at c h o l i n e r g i c r e c e p t o r s . M o l . P h a r m a c o l . , 6^, 3 5 7 - 3 8 2 . S c h a u f , C. L . , C. A. C o l t o n , J. S. C o l t o n and F. A . D a v i s ( 1 9 7 6 ) .

A n o t h e r t e s t for d r u g i n t e r a c t i o n p r o v e d i n c o n c l u s i v e : a f t e r e q u i l i ­ b r a t i n g a f i b r e in 4-AP w e c h a n g e d the p e r f u s a t e to a 4-AP-TEA m i x ­ ture and b a c k and w a t c h e d for t r a n s i e n t s in b l o c k d u r i n g a 1-Hz s e r i e s of test p u l s e s (see W a g n e r and U l b r i c h t , 1975 b , for t h e r a t i o n a l e of the e x p e r i m e n t ) . T r a n s i e n t s w e r e o b s e r v e d b u t n o t c o n s i s t e n t l y s o .

0745 for V = 0 , 1 0 , and 20 m V . F o r e i t h e r p r e p a r a t i o n , h o w e v e r , the v a l u e s seem to h a v e b e e n o b t a i n e d b y e x t r a p o l a t i o n r a t h ­ er than b y d i r e c t m e a s u r e m e n t s i n c e is m i n i m a l in this p o t e n t i a l region. 5 s ) . T h i s p r o t o c o l a v o i d e d p o s s i b l e s i d e - e f f e c t s of p r o l o n g e d d e p o l a r i z a t i o n s (however w e a k ) to f o l l o w b l o c k r e s t o r a t i o n to g o to c o m p l e t i o n .

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