Advances in Mucosal Immunology: Proceedings of the Fifth by P Brandtzaeg, K Bjerke, T S Halstensen, M Hvatum, K Kett, P

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By P Brandtzaeg, K Bjerke, T S Halstensen, M Hvatum, K Kett, P Krajci, D Kvale, F Müller (auth.), Thomas T MacDonald PhD MRCPath, Stephen J Challacombe PhD BDS MRCPath, Paul W Bland PhD, Christopher R Stokes PhD, Richard V Heatley MD MRCP, Allan Mcl Mowat Ph

The immunology of mucosal surfaces is likely one of the most fun and appropriate parts of clinical veterinary and dental study because it applies simple examine to tissues in­ volved in daily defence opposed to microbes and opposed to environmental and meals antigens. This ebook is predicated at the contributions offered on the overseas Con­ gress of Mucosal Immunology, held in London in July 1989 and organised through the Mu­ cosal Immunology Affinity staff of the British Society for Immunology. The meet­ ing used to be attended by means of over 500 delegates from 27 international locations, together with almost the entire prime investigators within the box. The contents supply entire and up-to­ date info on such issues as antigen presentation and processing within the intestine, mucosal vaccines in guy and animals, HIV an infection within the intestine, the function of yo T cells within the intestine epithelium, contemporary advances in inflammatory bowel affliction and coeliac dis­ ease, the function of cytokines within the law of the IgA reaction, mucosal mast cells and mobile migration. The contributions mirror the fast speed of study in mucosal immunology, and the nice strides that are happening within the realizing of the immunology, molecular biology and biochemistry of host reaction at mucosal sur­ faces.

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R. (1987) 'Immunoglobulin A (IgA): Molecular and cellular interactions involved in IgA biosynthesis and immune response', Advanc. Immunol. 40, 153-245. 6. E. L. ', Ann. Int. Med. 106, 892-899. 7. Mestecky, J. (1987) 'The common mucosal immune system and current strategies for induction of immune responses in external secretions', J. Clin. Immunol. 7, 265-276. 8. J. M. (1989) 'Structure and function of bronchus associated lymphoid tissue (BALT)', CRC Critical Rev. Immunol. 9, 119-150. 9. Brandtzaeg, P.

Schematic depiction of various putative mechanisms affording two levels of normal mucosal protection: (1) Secretory immunity performing immune exclusion {its enhancement against soluble dietary antigens may be afforded by contrasuppression releasing IgA- and IgM-producing cells from suppression}; and {2} suppression of systemic types of immunity to dietary antigens (leading to "oral tolerance"). 3 While B cells localize in the lamina propria and proliferate and differentiate there [4], many T cells find their way into the intestinal epithelium.

Immunol. 7, 265-276. 8. J. M. (1989) 'Structure and function of bronchus associated lymphoid tissue (BALT)', CRC Critical Rev. Immunol. 9, 119-150. 9. Brandtzaeg, P. (1987) 'Immune functions and immunopathology of palatine and nasopharyngeal tonsils', in J. Bernstein and P. ), Immunology of the Ear. Raven Press, New York, pp. 63-106. 10. L. C. (1986) 'Homing receptors and the control of lymphocyte migration', Immunol. Rev. 91, 39-60. 11. Duijvestijn, A. and Hamann, A. (1989) 'Mechanisms and regulation of lymphocyte migration', Immunol.

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